You should consult your doctor regarding how to come off a SSRI drug and switch to 5HTP.
Some patients may have experienced degeneration of serotonin-producing neurons and dopamine transmitters. This damage can be long-term. In some patients,
SSRI drugs such as Prozac may therefore be a better alternative than 5HTP as their brains are no longer able to produce normal serotonin levels the "natural" 5HTP
way. This is the sort of thing you should discuss with your doctor.
4) I've heard I should take Vitamin B3 with 5-HTP, should I be doing this also?
You only need to take additional Vitamin B3, if you already have a Vitamin B3 (Niacin) deficiency.
However, if you do have a Vitamin B3 deficiency, all of the 5-HTP you take may be used by your body to create Vitamin B3 - to make up this deficiency.
In other words, no 5-HTP will be left, after conversion to Vitamin B3, for conversion to serotonin.
More details about the nutritional links between Vitamin B3 and 5-HTP can be found in the article at the following link:
http://www.hypoglycemia.asn.au/articles/insomnia.html
Activated B3 can be purchased through the following link:
http://www.b2bworld.com.au/hp/prod269.htm
5) Is 5-HTP the same as L-Tryptophan?
No. 5-HTP is sometimes confused with L-Tryptophan. 5-HTP is the next step in the metabolic conversion of L-Tryptophan to serotonin.
The conversion chain is as follows:
L-Tryptophan --> 5-Hydroxy Tryptophan (5-HTP) (in the digestive system) --> Serotonin --> N-Acetyl-serotonin --> Melatonin (in the brain)
L-Tryptophan is one of the nine essential amino acids found in protein for human consumption. L-Tryptophan is found naturally in a range of proteins such as meat and turkey.
L-Tryptophan is called an essential amino acid because the human body is unable to create this amino acid, whereas it can create the other non-essential amino acids that make up the full protein spectrum.
6) Is it safe to take 5-HTP continuously on a long-term basis?
Whilst there is no evidence to suggest long-term use is unsafe, some healthcare professionals recommend taking it for 3 months, then having a two week break before resuming use - just to be on the safe side.